La3+-induced fusion of phosphatidylserine liposomes. Close approach, intermembrane intermediates, and the electrostatic surface potential
نویسندگان
چکیده
منابع مشابه
Pharmacokinetic characterization of phosphatidylserine liposomes
1 The plasma decay, tissue uptake and biotransformation of radiolabelled phosphatidylserine (PS) liposomes have been investigated in rats following bolus i.v. injection (2mg kg1). 2 PS plasma concentration showed a biexponential decay with half-lives of 0.85 and 40min. The following interpretation of the biphasic decay is proposed: (1) The rapid initial decline is due to the irreversible uptake...
متن کاملPoly(ethylene glycol)--lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine.
The effect of poly(ethylene glycol)--lipid (PEG--lipid) conjugates on liposomal fusion was investigated. Incorporation of PEG--lipids into large unilamellar vesicles (LUVs) composed of equimolar phosphatidylethanolamine (PE) and phosphatidylserine (PS) inhibited calcium-induced fusion. The degree of inhibition increased with increasing molar ratio of the PEG conjugate and with increasing size o...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1988
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(88)83138-2